FotoFinder bodystudio ATBM

FotoFinder Australia is proud to congratulate Prof. Cliff Rosendahl of Capalaba General Practice who, together with his colleagues and associates, has this week published a report documenting the World’s smallest published melanoma in the International Journal of Dermatology.

With a program of three-month follow-ups using FotoFinder bodystudio ATBM, including bodyscan and Fotofinder dermoscope using medicam 1000, the team detected the tiny, 0.6mm histologically, lesion on the patient’s thigh.

Fotofinder finds the World’s smallest published melanoma

Sir,

We report the smallest melanoma (0.9 mm and 0.6 mm in diameter dermatoscopically and histologically, respectively) in a 32-year-old female with a history of three melanomas in the previous 3 years. The patient was under automated total body photography follow-up at 3-month intervals (FotoFinder Bodystudio ATBM), and a new 0.9 mm diameter pigmented lesion on her left lateral thigh was detected (Fig. 1). At the time of presentation, dermatoscopic features included eccentric black clods, one pseudopod, and gray branched/reticular lines. All of these clues except the grey color were equivocal. There were no compelling clues to malignancy according to any of the published algorithms except chaos and clues. Although the lesion was reasonably symmetrical, according to Chaos and Clues, a small lesion with any of the nine defined clues to malignancy or any changing lesion on an adult should be considered for biopsy even if symmetrical.1 Consequently, after additional consideration that this was a high-risk patient, excisional biopsy was performed, and a pathology report of melanoma in situ was rendered.

Fotofinder finds the smallest published melanoma on the planet

International Journal of Dermatology – 2017

Histological examination (Fig. 2) was evaluated by three pathologists and revealed disorganized nests of melanocytes located at irregular intervals within the basal epidermis and con-fluence of single melanocytes. Isolated melanocytes were located within the granular and spinous layers. Occasional mitotic figures were observed within the junctional melanocytes. Dermal infiltration was not detected.  As most melanomas are larger than most melanocytic nevi, it is common practice for dermatoscopists not to pay attention to small lesions, with only the larger ones being examined by dermatoscopy. However, all melanomas begin as small lesions, which can subsequently grow in diameter and depth. This is consistent with the theory of tumorigenesis. If a cancer begins as one cell, then even a 1 mm melanoma has a malignant cell population at least in the thousands.2  This proposal is also consistent with stem cell theory that melanomas could develop from quiescent precursor cells that have accumulated a malignant complement of mutations.3 Any model proposed for melanomas developing from nevi, at best, can only be applied to a minority of melanomas, being fundamentally flawed for the vast majority which are known to develop de novo.

While it was asserted that there were no dermatoscopic criteria to distinguish nevi from in situ melanomas,4 the science of dermatoscopy has progressed to a stage where dermatoscopy is now known to improve accuracy for even in situ melanomas. 5 The clinical ABCDE acronym (asymmetry, border irregularity, color variegation, diameter >6 mm, evolution) was developed as a diagnostic approach for the early detection of cutaneous melanomas while the prognosis is still good. Critics have proposed that the existence of small melanomas (≤6 mm diameter) makes The clinical ABCDE acronym (asymmetry, border irregularity, color variegation, diameter >6 mm, evolution) was developed as a diagnostic approach for the early detection of cutaneous melanomas while the prognosis is still good. Critics have proposed that the existence of small melanomas (≤6 mm diameter) makes revision of the D criterion appropriate.2,6 Rosendahl et al., 7 suggested that in the clinical ABCD method, the D for diameter could be appropriately substituted with D for dynamic, arguing that the arbitrary designation of a diameter greater than 6 mm to the clinical diagnosis of melanoma, as in the clinical ABCD method, is inappropriate.

Previously dermatoscopic features of four minute melanomas with a diameter of 1.5–2 mm were reported.7–10 One of these minute melanomas was invasive.10 The present case, with a maximum diameter of 0.9 mm, is the smallest melanoma that has ever been reported, and it presented as a changing lesion on an adult with dermatoscopic subtle gray color, these features being sufficient according to the Chaos and Clues algorithm to warrant excisional biopsy.

The melanoma presented here, being 0.9 mm in diameter, is the smallest reported at this time. Every melanoma has to start small, and a threshold of 6 mm will prevent diagnosis at the earliest stages. We believe that especially in high risk patients, even very small lesions which have dermatoscopic clues to melanoma should be excised and submitted for pathological assessment.

Bengu N. Akay 1, MD
Aylin Okcu Heper 2, MD
Simon Clark 3,4, MB ChB FRCPA
Cengizhan Erdem 1, MD
Cliff O. Rosendahl 4,5, MBBS PhD
Harald Kittler 6, MD
1  Department of Dermatology, Ankara University Faculty of Medicine, Ankara, Turkey
2 Department of Pathology, Ankara University Faculty of Medicine, Ankara, Turkey
3 DHM Pathology, Macquarie Park, NSW, Australia
4 Tehran University of Medical Sciences, Tehran, Iran
5 School of Medicine, The University of Queensland, Brisbane, Australia
6 Department of Dermatology, Medical University of Vienna, Vienna, Austria
Conflict of Interest: None declared.
doi: 10.1111/ijd.13728
References
1 Rosendahl C, Cameron A, McColl I, et al. Dermatoscopy in routine practice – ‘chaos and clues’. Aust Fam Physician 2012; 41: 482–487.
2 Goldsmith SM, Solomon AR. A series of melanomas smaller than 4 mm and implications for the ABCDE rule. J Eur Acad Dermatol Venereol 2007; 21: 929–934.
3 Grichnik JM. Melanoma, nevogenesis, stem cell biology. J Invest Dermatol 2008; 128: 2365–2380.
4 Burroni M, Sbano P, Cevenini G, et al. Dysplastic naevus vs. in situ melanoma: digital dermoscopy analysis. Br J Dermatol 2005; 152: 679–684.
5 Rosendahl C, Tschandl P, Cameron A, et al. Diagnostic accuracy of dermatoscopy for melanocytic and nonmelanocytic pigmented lesions. J Am Acad Dermatol 2011; 64: 1068–1073.
6 Green J, Ackerman AB. A 6 mm for diameter in the ABCDs of melanoma? Dermatopathol Pract Concept 2000; 6: 379–382.
7 Rosendahl C, Drugge ED, Volpicelli ER, et al. Diagnosis of a minute melanoma assisted by automated multi camera array total body photography. Australas J Dermatol 2016; 57: 242–243.
8 Teng PP, Hofmann-Wellenhof R, Campbell TM, et al. Dermoscopic presentation of a 2-mm melanoma in situ. Australas J Dermatol 2010; 51: 152–153.
9 Rosendahl C, Cameron A, Bulinska A, et al. Dermatoscopy of a minute melanoma. Australas J Dermatol 2011; 52: 76–78.
10 Pellizzari G, Magee J, Weedon D, et al. A tiny invasive melanoma: a case report with dermatoscopy and dermatopathology. Dermatol Pract Concept 2013; 3: 49–51.

Download a copy of the Report:        Dermatoscopy of a melanoma less than one millimeter in diameter

 

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